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KMID : 1144320190510020183
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감염과 화학요법
2019 Volume.51 No. 2 p.183 ~ p.187
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Seroprevalence of Hepatitis A Virus in Pediatric Patients with Hematologic Malignancies after Chemotherapy and Hematopoietic Cell Transplantation
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Moon Ja-Un
Han A-Luem
Lee Eui-Soo
Kim Seong-Koo
Han Seung-Beom
Lee Jae-Wook
Chung Nack-Gyun
Cho Bin
Jeong Dae-Chul
Kang Jin-Han
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Abstract
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This retrospective study was performed to determine the seroprevalence of hepatitis A virus (HAV) in children and adolescents with hematologic malignancies after the completion of chemotherapy and hematopoietic cell transplantation (HCT). Of 97 enrolled patients, 60 (61.9%) were seropositive for HAV. The seroprevalences in patients undergoing chemotherapy and HCT were 60.3% (41/68) and 65.5% (19/29), respectively (P = 0.628). No significant factors associated with seropositivity for HAV after chemotherapy and HCT were identified. Anti-HAV tests and HAV re-vaccinations can be considered in children and adolescents with underlying hematologic malignancies after chemotherapy and HCT based on the anti-HAV results.
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KEYWORD
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Chemotherapy, Stem cell transplantation, Hepatitis A virus, Seroprevalence, Child
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